教师基本信息🥱：
姓名：孔星星
职称：教授
电子邮箱：kongxingxing@fudan.edu.cn
办公地点🤖：生科院D203
办公电话👏🏻🙍♂️：021-31246753
研究方向🤷🏽♀️：组织器官代谢与网络调控
个人简介：
教育及工作经历：
2021–至今 杏鑫 教授； 复旦附属华山医院 特聘教授
2017–2021美国加州大学洛杉矶分校 助理教授
2015–2017 哈佛大学贝斯以色列女执事医学中心（美国）讲师
2011–2015哈佛大学贝斯以色列女执事医学中心（美国）博士后
2006-2011中国医学科杏鑫&北京协和医杏鑫 博士
2001-2006中国医科大学 医学本科
授课情况：专业英语
招生专业：生理
科研项目：国家自然科学基金委员会，重大研究计划🫃🏿，92157203，骨骼肌干扰素调节因子4(IRF4)对机体代谢稳态的功能机制研究👨💼，2022-01-01至2025-12-31🫨，268万元，在研🌮，主持
代表性论文和论著：
第一作者或者通讯作者研究论文：
IRF3 promotes adipose inflammation and insulin resistance and represses browning.J Clin Invest. 126(8):2839-54, 2016. PMID: 27400129.
Sun J, Gao Y, Yao T, Huang Y, He Z, Kong X, Yu KJ, Wang RT, Guo H, Yan J, Chang Y, Chen H, Scherer PE, Liu T, Williams KW. Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons.Molecular Metabolism. 5(10):882-91, 2016. PMID: 27689001.
Chen Q, Yang X, Zhang H, Kong X, Yao L, Cui X, Zou Y, Fang F, Yang J, Chang Y. Metformin impairs systemic bile acid homeostasis through regulating SIRT1 protein levels.Biochim Biophys Acta. 1864(1):101-112, 2016. PMID: 27816442.
Yong G, Yao T, Deng Z, Sohn JW, Jia S, Huang Y, Kong X, Yu KJ, Wang RT, Chen H, Guo H, Yan J, Cunningham KA, Chang Y*, Liu T* and Williams KW*. TrpC5 mediates acute leptin and serotonin effects via Pomc neurons.Cell Reports. 18(3):583-592, 2017. PMID: 28099839.
Yao T, Deng Z, Gao Y, Sun J, Kong X, Huang Y, He Z, Xu Y, Chang Y, Yu KJ, Findley BG, Berglund ED, Wang RT, Guo H, Chen H, Li X, Kaufman RJ, Yan J, Liu T, Williams KW. Ire1α in Pomc neurons is required for thermogenesis and glycemia.Diabetes. 66(3):663-673, 2017. PMID: 28028078.
Yong G, Yao T, Deng Z, Sohn JW, Jia S, Huang Y, Kong X, Yu KJ, Wang RT, Chen H, Guo H, Yan J, Cunningham KA, Chang Y*, Liu T* and Williams KW*. TrpC5 mediates acute leptin and serotonin effects via Pomc neurons.Cell Reports. 18(3):583-592, 2017. PMID: 28099839.
Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Proc Natl Acad Sci USA. 114(30):7981-7986, 2017. PMID: 28630339
Kong X*#, Yao T*, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Tsai L, Kahn BB, Spiegelman BM, Liu T# and Rosen ED#. Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metabolism. 28:631–643, 2018. (*, co-first author🗃，#, co-corresponding author) PMID:30078553.
Zhu X*, Yao T*, Wang R*, Guo S, Wang X, Zhou Z, Zhang Y, Zhou X, Zhang Y, Zhuo X, Wang RT, Li ZJ#, Liu T#, Kong X#. IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway. Advanced Science. 7(19):2001502, 2020. PMID: 33042761.
Yao T, Yan H, Zhu X, Zhang Q, Kong X, Guo S, Feng Y, Wang H, Hua Y, Zhang J, Mittelman S, Tontonoz P, Zhou Z, Liu T, Kong X. Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome. Diabetes. 71:2256–2271, 2022. PMID: 35713959.
Guo S, Zhang S, Zhuang Y, Xie F, Wang R, Kong X, Zhang Q, Feng Y, Gao H, Kong X#, Liu T#. Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila. Proc Natl Acad Sci U S A. 120: e2213857120, 2023. PMID: 3694751.
Feng Y, Cui Z, Lu X, Gong H, Liu X, Wang H, Cheng H, Gao H, Shi X, Li Y, Ye H, Zhang Q#, Kong X#. Transcriptomics Dissection of Calorie Restriction and Exercise Training in Brown Adipose Tissue and Skeletal Muscle. Nutrients. 15: 1047, 2023. PMID: 36839405.
Zhang S, Yan H, Ding J, Wang R, Feng Y, Zhang X, Kong X, Gong H, Lu X, Ma A, Hua Y, Liu H, Guo J, Gao H, Zhou Z, Wang R#, Chen P#, Liu T#, Kong X#. Skeletal muscle-specific DJ-1 ablation-induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy. J. Cachexia Sarcopenia Muscle. 14(5):2126-2142, 2023. PMID: 37469245.
Guo S, Feng Y, Zhu X, Zhang X, Wang H, Wang R, Zhang Q, Li Y, Ren Y, Gao X, Bian H #, Liu T #, Gao H #, Kong X#. Metabolic crosstalk between skeletal muscle and liver through IRF4-FSTL1 in NASH. Nature Communications. 14(1):6047, 2023. PMID: 37770480.